Effect Of Dopamine Agonist And Antagonist On Dopamine Receptor 2 – In Silico Study

Abstract

Parkinson’s disease is one of neurological disease which have a highest death and prevalence rates. This disease has led to many severe symptoms such as bradykinesia, muscular rigidity, and resting tremor. Previous studies have shown that these Parkinsonian symptoms has related to dopamine receptor 2 (D2 receptor) whose density has some alteration on the early and later stages. However, the treatment for this dopamine receptor 2 density alteration has not been developed yet. Therefore, in this study, 3D modelling and molecular dynamics simulation will be used to construct the fully, optimized structure of dopamine receptor 2. Moreover, the interaction of dopamine agonist (roxindole) and antagonist (tiapride) with dopamine receptor 2 will clarify that the two mentioned compounds show potent and availability on the treatment of Parkinson’s disease using molecular docking.