| dc.description.abstract | Parkinson’s disease is one of neurological disease which have a highest death and prevalence
rates. This disease has led to many severe symptoms such as bradykinesia, muscular rigidity, and
resting tremor. Previous studies have shown that these Parkinsonian symptoms has related to
dopamine receptor 2 (D2 receptor) whose density has some alteration on the early and later
stages. However, the treatment for this dopamine receptor 2 density alteration has not been
developed yet. Therefore, in this study, 3D modelling and molecular dynamics simulation will be
used to construct the fully, optimized structure of dopamine receptor 2. Moreover, the
interaction of dopamine agonist (roxindole) and antagonist (tiapride) with dopamine receptor 2
will clarify that the two mentioned compounds show potent and availability on the treatment of
Parkinson’s disease using molecular docking. | en_US |
