| dc.description.abstract | Codonopsis javanica (Blume) Hook.f. & Thomson, commonly known as "đẳng sâm"
or "Dangshen", has been used in traditional Vietnamese medicine and is a
promising alternative source for Panax ginseng in pharmaceutical as well as
beverage industry. This study aimed to examine the extraction efficiency, the
presence of saponins and flavonoids, and the antimicrobial activity of C. javanica
root extracts using soxhlet and ultrasonic methods. The result showed that the
extraction efficiency given by solvents using ultrasonic method had the same
results as soxhlet method. To achieve the highest yields, it was recommended to
use the ultrasonic method with 50% methanol or 50% ethanol to extract C.
javanica root. The LC-MS results showed the presence of flavonoid – hesperidin
and saponins – lancemasides (A, C, D, E, and F) in C. javanica root extracts just
as in other Codonopsis species. The C. javanica root extract using ultrasonic
method with 50% methanol also performed the better results in obtaining the high
number and peak area of detected saponins and flavonoids. In this study, C.
javanica root extract at 10 mg/ml did not show antimicrobial activity on
Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Bacillus
subtilis (B. subtilis), Staphylococcus aureus (S. aureus) and Candida albicans (C.
albicans). | en_US |
