Green Synthesis Of Nanosilver From The Extract Of Syzygium Resinosum (Gagnep) In The Thermosensitive Chitosan Pluronic Hydrogel

Abstract

Trauma wound is an inevitable health issue in life. Many researchers have endeavored to develop multifunctional materials to enhance wound healing af ter injury. Syzygium resinosum (Gagnep), a plant with f resh leaves and decoction, is widely used in Vietnam and tropical countries to treat sof t tissue wounds, burns, skin infections, and periodontal diseases. Silver nanoparticles (AgNPs) synthesized using the herbal extract in Chitosan–Pluronic F127 copolymer (which plays roles in enhancing healing and protecting the colloidal nanosilver and plant bioactive components were used to create a thermosensitive polymeric nanocomposite solution that can form a multifunctional hydrogel film on the wound surface, in future studies. Phytochemical analysis was perf ormed to approximate the total phenolic content using the Folin–Ciocalteu method and antioxidant activities of the SR extract were tested using the DPPH radical scavenging assay. The synthesized products were characterized using different techniques, such as UV−visible spectroscopy, dynamic light scattering (DLS), X-ray diffraction (XRD), and transmission electron microscopy (TEM). The results proved that AgNPs were successfully synthesized in the copolymer using SR extract that would be further studied for biomedical applications.