| dc.description.abstract | Carpaine, a major alkaloid in papaya leaves, exhibits considerable cardiovascular
benefits alongside notable effects on muscle relaxation when utilized in medicine. In
this study, coupling of acid-base extraction and flotation was developed to completely
remove the use of toxic solvents. This method entails the extraction of carpaine from
Carica Papaya L. leaves using hot water extraction (HWE) alongside ultrasound assisted extraction (UAE) and the condensation of the species using surfactant assisted flotation. The acid-base extraction was applied to alter the solubility of
carpaine as desired at different stages of the process. The results showed that the
amount of carpaine extraction yield using all the treatments in conjunction was
significantly higher compared to control samples in which the acid-base extraction or
flotation was not applied. The TLC and GC-FID results suggested that the bubbles
introduced during the flotation were highly specific toward their interactions with
carpaine in its hydrophobic complex form. The amount of carpaine obtained using a
different method from previous study that utilized ethanolic extraction, in comparison
to the quantity of carpaine extracted using our method, our method exhibited a 2.32
-fold greater extraction yield. This work demonstrates the importance of flexible
utilization of both surface and bulk chemistry in achieving an improved solution for a
technical problem. | en_US |
